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J. Xiong, P. T. Fox, J. H. Gao. Directly mapping magnetic field effects of neuronal activity by magnetic resonance imaging. Hum Brain Mapp, 20(1):41-49, 2003.


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Magnetic resonance imaging (MRI) of brain functional activity relies principally on changes in cerebral hemodynamics, which are more spatially and temporally distributed than the underlying neuronal activity changes. We present a novel MRI technique for mapping brain functional activity by directly detecting magnetic fields induced by neuronal firing. Using a well-established visuomotor paradigm, the locations and latencies of activations in visual, motor, and premotor cortices were imaged at a temporal resolution of 100 msec and a spatial resolution of 3 mm, and were found to be in consistent with the electrophysiological and functional MRI (fMRI) literature. Signal strength was comparable to traditional event-related fMRI methods: about 1\% of the baseline signal. The magnetic-source MRI technique greatly increases the temporal accuracy in detecting neuronal activity, providing a powerful new tool for mapping brain functional organization in human and animals


[ *action potentials ] [ Brain/*physiology ] [ Brain mapping/*methods ] [ Female ] [ Human ] [ *magnetic resonance imaging ] [ Male ] [ Neurons/*physiology ] [ Support ] [ U.s. gov't ] [ Non-p.h.s. ] [ Support ] [ U.s. gov't ] [ P.h.s. ]


J. Xiong
P. T. Fox
J. H. Gao

BibTex Reference

   Author = {Xiong, J. and Fox, P. T. and Gao, J. H.},
   Title = {Directly mapping magnetic field effects of neuronal activity by magnetic resonance imaging},
   Journal = {Hum Brain Mapp},
   Volume = {20},
   Number = {1},
   Pages = {41--49},
   Year = {2003}

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