Jump to : Download | Abstract | Contact | BibTex reference | EndNote reference |


A. L. Vazquez, E. R. Cohen, V. Gulani, L. Hernandez-Garcia, Y. Zheng, G. R. Lee, S. G. Kim, J. B. Grotberg, D. C. Noll. Vascular dynamics and BOLD fMRI: CBF level effects and analysis considerations. Neuroimage, 32(4):1642-55, 2006.


Download paper: (link)

Copyright notice:This material is presented to ensure timely dissemination of scholarly and technical work. Copyright and all rights therein are retained by authors or by other copyright holders. All persons copying this information are expected to adhere to the terms and constraints invoked by each author's copyright. These works may not be reposted without the explicit permission of the copyright holder.


Changes in the cerebral blood flow (CBF) baseline produce significant changes to the hemodynamic response. This work shows that increases in the baseline blood flow level produce blood oxygenation-level dependent (BOLD) and blood flow responses that are slower and lower in amplitude, while decreases in the baseline blood flow level produce faster and higher amplitude hemodynamic responses. This effect was characterized using a vascular model of the hemodynamic response that separated arterial blood flow response from the venous blood volume response and linked the input stimulus to the vascular response. The model predicted the baseline blood flow level effects to be dominated by changes in the arterial vasculature. Specifically, it predicted changes in the arterial blood flow time constant and venous blood volume time constant parameters of +294% and -24%, respectively, for a 27% increase in the baseline blood flow. The vascular model performance was compared to an empirical model of the hemodynamic response. The vascular and empirical hemodynamic models captured most of the baseline blood flow level effects observed and can be used to correct for these effects in fMRI data. While the empirical hemodynamic model is easy to implement, it did not incorporate any explicit physiological information


A. L. Vazquez
E. R. Cohen
V. Gulani
L. Hernandez-Garcia
Y. Zheng
G. R. Lee
S. G. Kim
J. B. Grotberg
D. C. Noll

BibTex Reference

   Author = {Vazquez, A. L. and Cohen, E. R. and Gulani, V. and Hernandez-Garcia, L. and Zheng, Y. and Lee, G. R. and Kim, S. G. and Grotberg, J. B. and Noll, D. C.},
   Title = {Vascular dynamics and {BOLD} f{MRI}: {CBF} level effects and analysis considerations},
   Journal = {Neuroimage},
   Volume = {32},
   Number = {4},
   Pages = {1642--55},
   Year = {2006}

EndNote Reference [help]

Get EndNote Reference (.ref)