Jump to : Download | Abstract | Keywords | Contact | BibTex reference | EndNote reference |

TPB+05

K. Torquati, V. Pizzella, C. Babiloni, C. Del Gratta, S. Della Penna, A. Ferretti, R. Franciotti, P. M. Rossini, G. L. Romani. Nociceptive and non-nociceptive sub-regions in the human secondary somatosensory cortex: an MEG study using fMRI constraints. Neuroimage, 26(1):48-56, 2005.

Download

Download paper: (link)

Copyright notice:This material is presented to ensure timely dissemination of scholarly and technical work. Copyright and all rights therein are retained by authors or by other copyright holders. All persons copying this information are expected to adhere to the terms and constraints invoked by each author's copyright. These works may not be reposted without the explicit permission of the copyright holder.

Abstract

Previous evidence from functional magnetic resonance imaging (fMRI) has shown that a painful galvanic stimulation mainly activates a posterior sub-region in the secondary somatosensory cortex (SII), whereas a non-painful sensory stimulation mainly activates an anterior sub-region of SII [Ferretti, A., Babiloni, C., Del Gratta, C., Caulo, M., Tartaro, A., Bonomo, L., Rossini, P.M., Romani, G.L., 2003. Functional topography of the secondary somatosensory cortex for non-painful and painful stimuli: an fMRI study. Neuroimage 20 (3), 1625-1638.]. The present study, combining fMRI with magnetoencephalographic (MEG) findings, assessed the working hypothesis that the activity of such a posterior SII sub-region is characterized by an amplitude and temporal evolution in line with the bilateral functional organization of nociceptive systems. Somatosensory evoked magnetic fields (SEFs) recordings after alvanic median nerve stimulation were obtained from the same sample of subjects previously examined with fMRI [Ferretti, A., Babiloni, C., Del Gratta, C., Caulo, M., Tartaro, A., Bonomo, L., Rossini, P.M., Romani, G.L., 2003. Functional topography of the secondary somatosensory cortex for non-painful and painful stimuli: an fMRI study. Neuroimage 20 (3), 1625-1638.]. Constraints for dipole source localizations obtained from MEG recordings were applied according to fMRI activations, namely, at the posterior and the anterior SII sub-regions. It was shown that, after painful stimulation, the two posterior SII sub-regions of the contralateral and ipsilateral hemispheres were characterized by dipole sources with similar amplitudes and latencies. In contrast, the activity of anterior SII sub-regions showed statistically significant differences in amplitude and latency during both non-painful and painful stimulation conditions. In the contralateral hemisphere, the source activity was greater in amplitude and shorter in latency with respect to the ipsilateral. Finally, painful stimuli evoked a response from the posterior sub-regions peaking significantly earlier than from the anterior sub-regions. These results suggested that both ipsi and contra posterior SII sub-regions process painful stimuli in parallel, while the anterior SII sub-regions might play an integrative role in the processing of somatosensory stimuli

Keywords

[ Adult ] [ Electric stimulation ] [ Evoked potentials ] [ Somatosensory/physiology ] [ Female ] [ Humans ] [ Laterality/physiology ] [ Magnetic resonance imaging ] [ Magnetoencephalography ] [ Male ] [ Models ] [ Neurological ] [ Nociceptors/*physiology ] [ Oxygen/blood ] [ Pain threshold/physiology ] [ Research support ] [ Non-u.s. gov't ] [ Somatosensory cortex/*physiology ]

Contact

K. Torquati
V. Pizzella
C. Babiloni
C. Del Gratta
S. Della Penna
A. Ferretti
R. Franciotti
P. M. Rossini
G. L. Romani

BibTex Reference

@article{TPB+05,
   Author = {Torquati, K. and Pizzella, V. and Babiloni, C. and Del Gratta, C. and Della Penna, S. and Ferretti, A. and Franciotti, R. and Rossini, P. M. and Romani, G. L.},
   Title = {Nociceptive and non-nociceptive sub-regions in the human secondary somatosensory cortex: an {MEG} study using f{MRI} constraints},
   Journal = {Neuroimage},
   Volume = {26},
   Number = {1},
   Pages = {48--56},
   Year = {2005}
}

EndNote Reference [help]

Get EndNote Reference (.ref)