Jump to : Download | Abstract | Contact | BibTex reference | EndNote reference |

TFG06

M. E. Thomason, L. C. Foland, G. H. Glover. Calibration of BOLD fMRI using breath holding reduces group variance during a cognitive task. Hum Brain Mapp, 2006.

Download

Download paper: (link)

Copyright notice:This material is presented to ensure timely dissemination of scholarly and technical work. Copyright and all rights therein are retained by authors or by other copyright holders. All persons copying this information are expected to adhere to the terms and constraints invoked by each author's copyright. These works may not be reposted without the explicit permission of the copyright holder.

Abstract

The proportionality of blood oxygen level-dependent (BOLD) response during a cognitive task and that from a hypercapnic challenge was investigated in cortical structures involved in working memory (WM). Breath holding (BH) following inspiration was used to induce a BOLD response characteristic of regional vasomotor reactivity but devoid of metabolic changes. BOLD effects measured during BH were used to normalize individual subject activations during WM, which effectively reduced the confounding influence of individual- and region-specific differences in hemodynamic responsivity common to both tasks. In a study of seven subjects, the BH calibration reduced intersubject variability in WM effect amplitude by 24.8% (P < 0.03). Reduced intersubject variability resulted in a 23.7% increase in group WM activation voxel extent significant at P < 0.001, with further increases at more stringent thresholds. Because the BH task does not require CO(2) inhalation or other invasive manipulations and is broadly applicable across cortical regions, the proposed approach is simple to implement and may be beneficial for use not only in quantitative group fMRI analyses, but also for multicenter and longitudinal studies. Hum Brain Mapp, 2006. (c) 2006 Wiley-Liss, Inc

Contact

M. E. Thomason
L. C. Foland
G. H. Glover

BibTex Reference

@article{TFG06,
   Author = {Thomason, M. E. and Foland, L. C. and Glover, G. H.},
   Title = {Calibration of {BOLD} f{MRI} using breath holding reduces group variance during a cognitive task},
   Journal = {Hum Brain Mapp},
   Year = {2006}
}

EndNote Reference [help]

Get EndNote Reference (.ref)