Jump to : Download | Abstract | Keywords | Contact | BibTex reference | EndNote reference |

LES+03

E. Liebenthal, M. L. Ellingson, M. V. Spanaki, T. E. Prieto, K. M. Ropella, J. R. Binder. Simultaneous ERP and fMRI of the auditory cortex in a passive oddball paradigm. NeuroImage, 19(4):1395-1404, 2003.

Download

Download paper: (link)

Copyright notice:This material is presented to ensure timely dissemination of scholarly and technical work. Copyright and all rights therein are retained by authors or by other copyright holders. All persons copying this information are expected to adhere to the terms and constraints invoked by each author's copyright. These works may not be reposted without the explicit permission of the copyright holder.

Abstract

Infrequent occurrences of a deviant sound within a sequence of repetitive standard sounds elicit the automatic mismatch negativity (MMN) event-related potential (ERP). The main MMN generators are located in the superior temporal cortex, but their number, precise location, and temporal sequence of activation remain unclear. In this study, ERP and functional magnetic resonance imaging (fMRI) data were obtained simultaneously during a passive frequency oddball paradigm. There were three conditions, a STANDARD, a SMALL deviant, and a LARGE deviant. A clustered image acquisition technique was applied to prevent contamination of the fMRI data by the acoustic noise of the scanner and to limit contamination of the electroencephalogram (EEG) by the gradient-switching artifact. The ERP data were used to identify areas in which the blood oxygenation (BOLD) signal varied with the magnitude of the negativity in each condition. A significant ERP MMN was obtained, with larger peaks to LARGE deviants and with frontocentral scalp distribution, consistent with the MMN reported outside the magnetic field. This result validates the experimental procedures for simultaneous ERP/fMRI of the auditory cortex. Main foci of increased BOLD signal were observed in the right superior temporal gyrus [STG; Brodmann area (BA) 22] and right superior temporal plane (STP; BA 41 and 42). The imaging results provide new information supporting the idea that generators in the right lateral aspect of the STG are implicated in processes of frequency deviant detection, in addition to generators in the right and left STP

Keywords

[ Adult ] [ Arousal/physiology ] [ Attention/*physiology ] [ Auditory cortex/*physiology ] [ Brain mapping ] [ Contingent negative variation/*physiology ] [ *electroencephalography ] [ Evoked potentials ] [ Auditory/*physiology ] [ Female ] [ Human ] [ *image processing ] [ Computer-assisted ] [ *magnetic resonance imaging ] [ Male ] [ Middle aged ] [ Nerve net/physiology ] [ Oxygen consumption/physiology ] [ Pitch discrimination/*physiology ] [ Support ] [ U.s. gov't ] [ P.h.s. ] [ Temporal lobe/physiology ]

Contact

E. Liebenthal
M. L. Ellingson
M. V. Spanaki
T. E. Prieto
K. M. Ropella
J. R. Binder

BibTex Reference

@article{LES+03,
   Author = {Liebenthal, E. and Ellingson, M. L. and Spanaki, M. V. and Prieto, T. E. and Ropella, K. M. and Binder, J. R.},
   Title = {Simultaneous {ERP} and f{MRI} of the auditory cortex in a passive oddball paradigm},
   Journal = {NeuroImage},
   Volume = {19},
   Number = {4},
   Pages = {1395--1404},
   Year = {2003}
}

EndNote Reference [help]

Get EndNote Reference (.ref)