Jump to : Download | Abstract | Keywords | Contact | BibTex reference | EndNote reference |

KWW+99

K. Krakow, U. C. Wieshmann, F. G. Woermann, M. R. Symms, M. A. McLean, L. Lemieux, P. J. Allen, G. J. Barker, D. R. Fish, J. S. Duncan. Multimodal MR imaging: functional, diffusion tensor, and chemical shift imaging in a patient with localization-related epilepsy. Epilepsia, 40(10):1459-1462, 1999.

Download

Download paper: (link)

Copyright notice:This material is presented to ensure timely dissemination of scholarly and technical work. Copyright and all rights therein are retained by authors or by other copyright holders. All persons copying this information are expected to adhere to the terms and constraints invoked by each author's copyright. These works may not be reposted without the explicit permission of the copyright holder.

Abstract

PURPOSE: To demonstrate the integration of complementary functional and structural data acquired with magnetic resonance imaging (MRI) in a patient with localization-related epilepsy. METHODS: We studied a patient with partial and secondarily generalized seizures and a hemiparesis due to a malformation of cortical development (MCD) in the right hemisphere by using EEG-triggered functional MRI (fMRI), diffusion tensor imaging (DTI), and chemical shift imaging (CSI). RESULTS: fMRI revealed significant changes in regional blood oxygenation associated with interictal epileptiform discharges within the MCD. DTI showed a heterogeneous microstructure of the MCD with reduced fractional anisotropy, a high mean diffusivity, and displacement of myelinated tracts. CSI demonstrated low N-acetyl aspartate (NAA) concentrations in parts of the MCD. CONCLUSIONS: The applied MR methods described functional, microstructural, and biochemical characteristics of the epileptogenic tissue that cannot be obtained with other noninvasive means and thus improve the understanding of the pathophysiology of epilepsy

Keywords

[ Adult ] [ Anisotropy ] [ Aspartic acid/analogs & derivatives/analysis ] [ Cerebral cortex/abnormalities/chemistry/physiopathology ] [ Electroencephalography/statistics & numerical data ] [ Epilepsies ] [ Partial/blood/*diagnosis/physiopathology ] [ Human ] [ Magnetic resonance imaging/methods/*statistics & numerical data ] [ Male ] [ Nervous system malformations/diagnosis ] [ Oxygen/blood ]

Contact

K. Krakow
U. C. Wieshmann
F. G. Woermann
M. R. Symms
M. A. McLean
L. Lemieux
P. J. Allen
G. J. Barker
D. R. Fish
J. S. Duncan

BibTex Reference

@article{KWW+99,
   Author = {Krakow, K. and Wieshmann, U. C. and Woermann, F. G. and Symms, M. R. and McLean, M. A. and Lemieux, L. and Allen, P. J. and Barker, G. J. and Fish, D. R. and Duncan, J. S.},
   Title = {Multimodal {MR} imaging: functional, diffusion tensor, and chemical shift imaging in a patient with localization-related epilepsy},
   Journal = {Epilepsia},
   Volume = {40},
   Number = {10},
   Pages = {1459--1462},
   Year = {1999}
}

EndNote Reference [help]

Get EndNote Reference (.ref)