Jump to : Download | Abstract | Keywords | Contact | BibTex reference | EndNote reference |

KRO+04

D. S. Kim, I. Ronen, C. Olman, S. G. Kim, K. Ugurbil, L. J. Toth. Spatial relationship between neuronal activity and BOLD functional MRI. Neuroimage, 21(3):876-85, 2004.

Download

Download paper: (link)

Copyright notice:This material is presented to ensure timely dissemination of scholarly and technical work. Copyright and all rights therein are retained by authors or by other copyright holders. All persons copying this information are expected to adhere to the terms and constraints invoked by each author's copyright. These works may not be reposted without the explicit permission of the copyright holder.

Abstract

Despite the ubiquitous use of functional magnetic resonance imaging (fMRI), the extent to which the magnitude and spatial scale of the fMRI signal correlates with neuronal activity is poorly understood. In this study, we directly compared single and multiunit neuronal activity with blood oxygenation level-dependent (BOLD) fMRI responses across a large area of the cat area 18. Our data suggest that at the scale of several millimeters, the BOLD contrast correlates linearly with the underlying neuronal activity. At the level of individual electrode recording sites, however, the correlation between the two signals varied substantially. We conclude from our study that T(2)*-based positive BOLD signals are a robust predictor for neuronal activity only at supra-millimeter spatial scales

Keywords

[ Animals ] [ Brain/cytology/*physiology ] [ Cats ] [ Cerebral cortex/cytology/physiology ] [ Cerebrovascular circulation/physiology ] [ Electrodes ] [ Implanted ] [ Magnetic resonance imaging ] [ Neurons/*physiology ] [ Oxygen/*blood ] [ Photic stimulation ] [ Research support ] [ Non-u.s. gov't ] [ Research support ] [ U.s. gov't ] [ P.h.s. ] [ Visual cortex/cytology/physiology ]

Contact

D.S. Kim
I. Ronen
C. Olman
S. G. Kim
K. Ugurbil
L. J. Toth

BibTex Reference

@article{KRO+04,
   Author = {Kim, D. S. and Ronen, I. and Olman, C. and Kim, S. G. and Ugurbil, K. and Toth, L. J.},
   Title = {Spatial relationship between neuronal activity and {BOLD} functional {MRI}},
   Journal = {Neuroimage},
   Volume = {21},
   Number = {3},
   Pages = {876--85},
   Year = {2004}
}

EndNote Reference [help]

Get EndNote Reference (.ref)