Jump to : Download | Abstract | Keywords | Contact | BibTex reference | EndNote reference |

GPA+03

D. R. Gitelman, W. D. Penny, J. Ashburner, K. J. Friston. Modeling regional and psychophysiologic interactions in fMRI: the importance of hemodynamic deconvolution. NeuroImage, 19(1):200-207, 2003.

Download

Download paper: (link)

Copyright notice:This material is presented to ensure timely dissemination of scholarly and technical work. Copyright and all rights therein are retained by authors or by other copyright holders. All persons copying this information are expected to adhere to the terms and constraints invoked by each author's copyright. These works may not be reposted without the explicit permission of the copyright holder.

Abstract

The analysis of functional magnetic resonance imaging (fMRI) time-series data can provide information not only about task-related activity, but also about the connectivity (functional or effective) among regions and the influences of behavioral or physiologic states on that connectivity. Similar analyses have been performed in other imaging modalities, such as positron emission tomography. However, fMRI is unique because the information about the underlying neuronal activity is filtered or convolved with a hemodynamic response function. Previous studies of regional connectivity in fMRI have overlooked this convolution and have assumed that the observed hemodynamic response approximates the neuronal response. In this article, this assumption is revisited using estimates of underlying neuronal activity. These estimates use a parametric empirical Bayes formulation for hemodynamic deconvolution

Keywords

[ Bayes theorem ] [ *brain mapping ] [ Hemodynamic processes ] [ Human ] [ *magnetic resonance imaging ] [ *models ] [ Neurological ] [ Neurons/physiology ] [ *psychophysiology ] [ Support ] [ Non-u.s. gov't ] [ Support ] [ U.s. gov't ] [ P.h.s. ]

Contact

D. R. Gitelman
W. D. Penny
J. Ashburner
K. J. Friston

BibTex Reference

@article{GPA+03,
   Author = {Gitelman, D. R. and Penny, W. D. and Ashburner, J. and Friston, K. J.},
   Title = {Modeling regional and psychophysiologic interactions in f{MRI}: the importance of hemodynamic deconvolution},
   Journal = {NeuroImage},
   Volume = {19},
   Number = {1},
   Pages = {200--207},
   Year = {2003}
}

EndNote Reference [help]

Get EndNote Reference (.ref)