Jump to : Download | Abstract | Contact | BibTex reference | EndNote reference |


P. Grummich, C. Nimsky, E. Pauli, M. Buchfelder, O. Ganslandt. Combining fMRI and MEG increases the reliability of presurgical language localization: A clinical study on the difference between and congruence of both modalities. Neuroimage, 2006.


Download paper: (link)

Copyright notice:This material is presented to ensure timely dissemination of scholarly and technical work. Copyright and all rights therein are retained by authors or by other copyright holders. All persons copying this information are expected to adhere to the terms and constraints invoked by each author's copyright. These works may not be reposted without the explicit permission of the copyright holder.


To avoid neurological impairment during surgery near language-related eloquent brain areas, we performed presurgical functional brain mapping with functional magnetic resonance imaging (fMRI) and magnetoencephalography (MEG) in 172 patients using language tasks. For MEG localizations, we used either a moving equivalent-current dipole fit or a current-density reconstruction using a minimum variance beamformer with a spatial filter algorithm. We localized the Wernicke and Broca language areas for every patient. We integrated the results into a frameless stereotaxy system. To visualize the results in the navigation microscope during surgery, we superimposed the fMRI and MEG findings on the brain surface. MEG and fMRI results differed in 4% of cases, and in 19%, one modality showed activation but not the other. In the vicinity of large gliomas, the BOLD (blood oxygenation level-dependent) effect was suppressed in 53% of our patients. Of the 124 patients who had surgery, only 7 patients (5.6%) experienced a transient language deterioration, which resolved in all cases. We used MEG and fMRI to show different aspects of brain activity and to establish validation between MEG and fMRI. We conclude that measurement by both MEG and fMRI increases the degree of reliability of language area localization and that the combination of fMRI and MEG is useful for presurgical localization of language-related eloquent cortex


P. Grummich
C. Nimsky
E. Pauli
M. Buchfelder
O. Ganslandt

BibTex Reference

   Author = {Grummich, P. and Nimsky, C. and Pauli, E. and Buchfelder, M. and Ganslandt, O.},
   Title = {Combining f{MRI} and {MEG} increases the reliability of presurgical language localization: {A} clinical study on the difference between and congruence of both modalities},
   Journal = {Neuroimage},
   Year = {2006}

EndNote Reference [help]

Get EndNote Reference (.ref)