Jump to : Download | Abstract | Keywords | Contact | BibTex reference | EndNote reference |


M. Brazdil, M. Dobsik, M. Mikl, P. Hlustik, P. Daniel, M. Pazourkova, P. Krupa, I. Rektor. Combined event-related fMRI and intracerebral ERP study of an auditory oddball task. Neuroimage, 26(1):285-93, 2005.


Download paper: (link)

Copyright notice:This material is presented to ensure timely dissemination of scholarly and technical work. Copyright and all rights therein are retained by authors or by other copyright holders. All persons copying this information are expected to adhere to the terms and constraints invoked by each author's copyright. These works may not be reposted without the explicit permission of the copyright holder.


Event-related fMRI (efMRI) has been repeatedly used to seek the neural sources of endogenous event-related potentials (ERP). However, significant discrepancies exist between the efMRI data and the results of previously published intracranial ERP studies of oddball task. To evaluate the capacity of efMRI to define the sources of the P3 component of ERP within the human brain, both efMRI and intracerebral ERP recordings were performed in eight patients with intractable epilepsy (five males and three females) during their preoperative invasive video-EEG monitoring. An identical auditory oddball task with frequent and target stimuli was completed in two sessions. A total of 606 intracerebral sites were electrophysiologically investigated by means of depth electrodes. In accordance with the finding of multiple intracerebral generators of P3 potential, the target stimuli evoked MRI signal increase in multiple brain regions. However, regions with evident hemodynamic and electrophysiological responses overlapped only partially. P3 generators were always found within hemodynamic-active sites, if these sites were investigated by means of depth electrodes. On the other hand, unequivocal local sources of P3 potential were apparently also located outside the regions with a significant hemodynamic response (typically in mesiotemporal regions). Both methods should thus be viewed as mutually complementary in investigations of the spatial distribution of cortical and subcortical activation during oddball task


[ Adult ] [ Auditory cortex/physiology ] [ Auditory perception/*physiology ] [ Brain/*physiology ] [ Cerebrovascular circulation/physiology ] [ Electrodes ] [ Implanted ] [ Electroencephalography ] [ Electrophysiology ] [ Epilepsy/physiopathology ] [ Evoked potentials ] [ Auditory/physiology ] [ Female ] [ Humans ] [ Magnetic resonance imaging ] [ Male ] [ Oxygen/blood ] [ Research support ] [ Non-u.s. gov't ]


M. Brazdil
M. Dobsik
M. Mikl
P. Hlustik
P. Daniel
M. Pazourkova
P. Krupa
I. Rektor

BibTex Reference

   Author = {Brazdil, M. and Dobsik, M. and Mikl, M. and Hlustik, P. and Daniel, P. and Pazourkova, M. and Krupa, P. and Rektor, I.},
   Title = {Combined event-related f{MRI} and intracerebral {ERP} study of an auditory oddball task},
   Journal = {Neuroimage},
   Volume = {26},
   Number = {1},
   Pages = {285--93},
   Year = {2005}

EndNote Reference [help]

Get EndNote Reference (.ref)